[Family-based association study of dopaminergic genes polymorphisms and EAS temperamental traits].

AIM The aim of the present study was to identify relations between several polymorphisms in dopamine genes (DRD2, DRD3, DRD4, SNAP-25, ANKKland DATI) and temperamental traits distinguished in the EAS theory. In this study the family-based method was used. METHOD The study was run on 149 biological families with one or two children aged 3-12. Temperamental data were obtained using Buss and Plomin EAS-C Temperament Questionnaire. RESULTS Significant associations between two SNPs in the SNAP-25 gene (rs363039 and rs363050) and shyness was found. Significant relationships of this trait with haplotypes in DAT1 and SNAP-25 genes was also identified. CONCLUSION The data collected suggest that variability in dopamine genes may have impact on the development of temperamental shyness, which is recognized as a fear of strangers.